• Funding period:
  • January 2023 – December 2024
  • Funding organization:
  • MeDDrive program by Medical Faculty Carl Gustav Carus of the TUD

Project description:

Lipid mobilization, interorgan transport and absorption within the body provide a functional readout of systemic lipid metabolism. The clinical lipid panel reports concertation of triglycerides, cholesterol, and phospholipids in different lipoprotein fractions to support diagnosis and prognosis of metabolic risks and disorders. Despite the clear significance of lipoprotein lipid component to systemic lipid metabolism, the lipoprotein lipidome and its remodelling in metabolic pathologies remain poorly characterized.

Hepatocytes represent an excellent system to study the cross talk between cellular and systemic lipid metabolism, as they do not only store lipids in lipid droplets but also export them into the circulation in the form of very‑low density lipoproteins (VLDLs). By using mass spectrometry based lipidomic approaches in a model system consisting of healthy and steatotic hepatocytes, this project aims to obtain a detailed molecular description of metabolic and bioactive lipids secreted in VLDLs under physiological and pathological conditions. This will enhance our current understanding on the liver and the whole body metabolic crosstalk in physiological and pathological conditions.

Involved LMAI members:

Current projects:

Understanding dynamics of lipid metabolism and oxidation in ferroptotic cell death programme

Ferroptosis as a common underlying pathomechanism in tissue ischemia/reperfusion injury

Pan-European Network in Lipidomics and EpiLipidomcis

Dysregulated systemic release of metabolic and bioactive lipids along hepatocyte-VLDL axis

Extension of the Lipidomics technology platform to include targeted high-throughput phenotyping of lipid metabolism and its remodelling

Apply machine learning and deep learning methods to (epi)lipidomics data analysis

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