About us

Fedorova Lab #LMAI

Here at “Lipid Metabolism: Analysis and Integration” (LMAI) we look at this amazing diversity of lipids by using advanced bioanalytical and computational tools. With mass spectrometry (MS) based lipidomics and epilipidomics we can take apart complex lipidomes down to the lipid molecular species level to detect and quantify even fine alterations in lipid metabolism. And then, using our computational tools we assemble this information into the detailed metabolic maps reflecting the biological status of the system.

At LMAI, we are specifically interested in:

  • Tissue lipidomes as metabolic units
  • Plasticity of lipid metabolism in stress responses
  • Lipid and lipidome quality control (at subcellular, cellular, tissue and organismal levels)
  • Concept of epilipidome, as a subset of natural lipidome formed by lipid modifications, aiming to increase regulatory capacity of biological systems

Why is it important? Lipids have huge biomedical potential in:

  • Understanding numerous metabolic disorders which emerged in pandemic proportions in the modern world. We are specifically looking at the alteration in lipid metabolism in obesity, diabetes, NAFLD and cancer.
  • When better understood, lipid metabolism can be targeted pharmacologically. Thus, we are searching for metabolic vulnerabilities which can help to combat metabolic or malignant diseases.
  • Lipids can serve as biomarkers and help to monitor the success of drug development. With MS instruments already present in clinical labs, lipids have a high potential for clinical translations as predictive, diagnostic, and prognostic biomarkers.

 

As a tradition every December, we had a special Friday lab seminar where Maria put together all what we have achieved as a team in 2023.

Contacts
  • Fedorova Lab
  • Center for Membrane Biochemistry and Lipid Research (ZML)
    TU Dresden
  • Address: Tatzberg 47/49, 01307 Dresden

🫧 Special Issue! #LipidDroplets in Health and Disease

👩‍🔬 Guest editors: @MariaBohnert & @BiancaSchrul

➡️ http://bit.ly/44SET8Z

16 reviews highlight new discoveries in the lipid droplet lifecycle and insights into diseases related to lipid storage.

@wwu_muenster @Saar_Uni

California Lipid Community: We will host the 1st Bay Area Lipidomics Meeting on August 9th at UC Berkeley! Registration is free: http://t.ly/8IoD3 Please join us for a day full of exciting lipidomics-focused science presented by a stellar speaker lineup! #BALM #lipidomics

Here’s the big one: In collaboration with @Honigmann_Lab, @LabShevchenko, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
https://www.biorxiv.org/content/10.1101/2024.05.14.594078v1

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  • Fedorova Lab #LMAI
  • Center of Membrane Biochemistry and Lipid Research (ZML)
  • Address: Tatzberg 47/49, 01307 Dresden
  • Copyright 2023 Fedorova Lab, LMAI
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