Our team combines biochemical knowledge on lipid metabolism with high-end lipidomics technologies. We hold a strong background in the analytical method development with a specific focus on liquid chromatography (LC) and mass spectrometry (MS) analysis of lipids in a variety of biological matrices. Over the last years LMAI team established several high-throughput LC-MS workflows based on the application of different LC types (reversed phase (RP) and hydrophilic interaction liquid chromatography (HILIC)) coupled on-line to MS detection for identification and quantification of lipids. In the last few years we have especially focused on setting up robust and high-throughput methods for in-depth identification and absolute quantification of lipids in human tissues (e.g. white adipose tissue, aortic valve) and blood plasma samples which we now can apply to larger cohort studies focused on defining lipid fingerprints associated with metabolic diseases.
We believe in open science and provide all our datasets to the community! You can find more information about publicly available raw and metadata resulted from our studies at Resources page.