• Funding period:
  • July 2022 – June 2025
  • Funding organization:
  • Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)

Consortium description:

FERROpath is an interdisciplinary biomedical consortium funded by the German Federal Ministry of Education and Research bringing clinicians, molecular- and cell biologists, and bioanalytical chemists from Dresden, Munich, Regensburg, and Essen together to uncover common pathomechanistic signatures and to develop urgently needed biomarkers of ischemia-reperfusion injury (IRI) occurring during conditions of high clinical relevance such as stroke, acute kidney injury, and tissue damage upon organ transplantation.

Consortium Partners:
  • Bettina Proneth and Marcus Conrad, Helmholtz Zentrum München
  • Andreas Linkermann, University Hospital CGC of the TU Dresden
  • Elke Eggenhofer and Edward Geissler, University Hospital Regensburg
  • Aicha Jeridi and Ali Önder Yildirim, Helmholtz Zentrum München
  • Ana I. Casas and Christoph Kleinschnitz, University Hospital Essen

Project description:

Within FERROPath our team’s innovative approach is centred on a shared pathophysiological feature of IRI which is tissue degeneration via ferroptotic cell death. Ferroptosis, a form of regulated necrotic cell death causing substantial and highly specific pathobiochemical alterations in the lipidome of tissues experiencing IRI. One of the hallmark of ferroptosis is accumulation of oxidized phospholipids. Hence, putting the focus on lipids, we aim to define the lipidomic fingerprint of IRI using our broad expertise in bioanalytical mass spectrometry of native and oxidized lipids. Furthermore, we will use this knowledge to identify ferroptosis-linked biomarkers for monitoring of disease progression, therapeutic outcomes, and screening and validation of novel ferroptotic inhibitors in the treatment of IRI-linked diseases, as well as in the preservation of transplant organs.

Involved LMAI members:

Current projects:

Understanding dynamics of lipid metabolism and oxidation in ferroptotic cell death programme

Ferroptosis as a common underlying pathomechanism in tissue ischemia/reperfusion injury

Pan-European Network in Lipidomics and EpiLipidomcis

Dysregulated systemic release of metabolic and bioactive lipids along hepatocyte-VLDL axis

Extension of the Lipidomics technology platform to include targeted high-throughput phenotyping of lipid metabolism and its remodelling

Apply machine learning and deep learning methods to (epi)lipidomics data analysis

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