FOSTER

Ageing is an omnipresent process that directly influences every human life and plays a significant role in our society. Biomedically, understanding the underlying mechanisms of ageing is crucial, as it will pave the way to a healthier and potentially extended lifespan for humans. So far, the majority of research in ageing was focused on elucidating the role of DNA and protein homeostasis. However, lipids, which are closely linked to all metabolic processes, remains relatively understudied in age-related research.

To gain deeper understanding in lipid quality control and lipostasis during ageing, we will compare age-dependent remodeling of the lipidome in two model organisms: (1) in mice, representing short-lived and fast-ageing animals, and (2) axolotls (Ambystoma mexicanum), a Mexican salamander know for its slow ageing and long life span. This project aims to uncover unique lipid signatures associated with the axolotl’s remarkable longevity and resistance to ageing-related changes and further explore the immense toolbox of evolution. The project will be performed in close collaboration with a Regenerative Biology lab led by Dr. Max H Yun, seeking to understand the principles of regeneration and ageing using salamanders.